Speciogynine

Speciogynine is a diastereomer of mitragynine and typically the third- or fourth-most abundant alkaloid in kratom, comprising roughly 7–21% of total alkaloid content. Like paynantheine, speciogynine acts primarily as a smooth muscle relaxant rather than an opioid receptor agonist. It has negligible activity at the mu-opioid receptor and does not contribute meaningfully to kratom's analgesic or euphoric effects. Its smooth muscle relaxant properties may contribute to some of the gastrointestinal and vascular effects reported by kratom users. As a diastereomer of mitragynine (same molecular formula, different spatial arrangement), speciogynine demonstrates how small structural differences can result in dramatically different pharmacological profiles. Research into speciogynine remains limited, and its precise role in kratom's overall effect profile is still being characterized.

Appears on Certificates of Analysis as: SPEC. Graded under Alkaloid Profile (Moderate component).