MGM-15
MGM-15 · CAS n/a
Formula
C₂₄H₃₂N₂O₅
Molecular Weight
428.53 g/mol
Abundance in Leaf
Synthetic
Last Reviewed
2026-03-12
What Is MGM-15?
MGM-15 is a synthetic analog of mitragynine designed to enhance G-protein signalling while maintaining low beta-arrestin recruitment. It acts as a partial agonist at the mu-opioid receptor with moderate affinity (Ki ~35 nM). Preclinical data shows antinociception without significant respiratory depression at equianalgesic doses. MGM-15 is a tool compound used in pharmacological research to study biased agonism — it is not found in kratom or consumer products.
Dose-Dependent Effects
Receptor Activity
Safety & Adverse Effects
Research status
MGM-15 is a synthetic research compound. All pharmacological data is preclinical. Not present in any consumer product.
Source: Váradi et al. 2016
Drug Interactions
COA Connection
Appears on Certificates of Analysis as: N/A. Graded under Not measured on COAs (Synthetic research compound).
View graded productsCited Literature
Váradi A, Marrone GF, Palmer TC, et al. (2016). Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2. J Am Chem Soc.
DOI: 10.1021/jacs.6b00360